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Charting a metagenomic atlas of the uncultured microbiome in health and disease

The human gut microbiome plays an important role in many aspects of human health and disease, including colorectal cancer, inflammatory bowel disease and type 2 diabetes. However, there are over 3,000 gut bacterial species across the world that still remain uncultured to date, and therefore inaccessible to experimental manipulation.

In this talk I will showcase how large-scale metagenomic approaches have allowed us to shed new light into the role of the uncultured microbiome across various diseases and its potential diagnostic application.

I will also highlight how studying the interaction between the microbiome and opportunistic pathogens in the gut may help develop alternative therapeutic strategies for mitigating the emergence of multidrug-resistant infections worldwide.